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A4. ANTIBIOTIC-INDUCED RESISTANCE FLOW

In , she came to NIAID as the influenza and viral respiratory diseases program officer in DMID and, in , she was appointed chief of the respiratory diseases branch where she coordinated the development of acellular pertussis vaccines.

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She is the recipient of several notable awards for outstanding achievement. Throughout her extramural career, Dr. Heilman has contributed articles on vaccine design and development to many scientific journals and has served as a consultant to the World Bank and WHO in this area. She is also a member of several professional societies, including the Infectious Diseases Society of America, the American Society for Microbiology, and the American Society of Virology. From to , prior to joining WHO, Dr Heymann spent 13 years working as a medical epidemiologist in sub-Saharan Africa Cameroon, Ivory Coast, the former Zaire, and Malawi on assignment from the Centers for Disease Control and Prevention CDC in CDC-supported activities aimed at strengthening capacity in surveillance of infectious diseases and their control, with special emphasis on the childhood immunizable diseases, African hemorrhagic fevers, pox viruses, and malaria.

While based in Africa, Dr. Heymann participated in the investigation of the first outbreak of Ebola in Yambuku former Zaire in , then again investigated the second outbreak of Ebola in in Tandala, and in directed the international response to the Ebola outbreak in Kikwit. Prior to , Dr. Heymann holds a B. He has published scientific articles on infectious diseases in peer-reviewed medical and scientific journals. He completed a residency in internal medicine at the University of Washington and a fellowship in infectious diseases at the University of Virginia. He is board-certified in internal medicine, infectious diseases, and preventive medicine.

During his CDC career, he has worked primarily in the areas of foodborne disease and infection control in health care settings. The center is currently working to address domestic and global challenges posed by emerging infectious diseases and the threat of bioterrorism. KATZ, M. He has concentrated his research on infectious diseases, focusing primarily on vaccine research, development, and policy. Katz has served on a number of scientific advisory committees and is the recipient of many prestigious awards and honorary fellowships in international organizations.

He attained his M. He became a staff member at Children's Hospital, working with Nobel laureate John Enders, during which time they developed the attenuated measles virus vaccine now used throughout the world. Katz's published studies include abundant original scientific articles, chapters in textbooks, and many abstracts, editorials, and reviews. He is the coeditor of a textbook on pediatric infectious diseases and has given many named lectures in the United States and abroad. Currently he co-chairs the Indo-U.

He obtained his M. He is board-certified in general preventive medicine and a fellow of the American College of Preventive Medicine. Colonel Kelley has extensive experience leading military infectious disease studies and in managing domestic and international public health surveillance efforts. He has spoken before professional audiences in over 15 countries and has authored or co-authored over 50 scientific papers and book chapters on a variety of infectious disease and preventive medicine topics.

He serves as the specialty editor for a textbook entitled, Military Preventive Medicine: Mobilization and Deployment. This bureau is responsible for the surveillance and control of 62 infectious diseases and conditions reportable under the New York City Health Code. Current areas of concern include antibiotic resistance; foodborne, waterborne, and tickborne diseases; hepatitis C; and biological disaster planning for the potential threats of bioterrorism and pandemic influenza.

Layton received her medical degree from Duke University. In addition, Dr. His lifelong research, for which he received the Nobel Prize in , has been in genetic structure and function in microorganisms. He has a keen interest in international health and was co-chair of a previous Institute of Medicine Committee on Emerging Microbial Threats to Health — and currently is co-chair of the Committee on Emerging Microbial Threats to Health in the 21st Century.

He has been a member of the National Academy of Sciences since and is a charter member of the Institute of Medicine. After his fellowship he was appointed assistant professor of pathology at the University of Minnesota, where he did his research on cytomegalovirus infections in renal transplant recipients and the consequences of those infections. He was next appointed assistant member and head of the Laboratory of Herpesvirus Infections at the Sloan Kettering Institute for Cancer Research, where his research focused on herpes virus infections and the resistance mechanisms involved.

He is co-author of one of the seminal publications on this disease, as well as many scientific papers, and co-editor of six books. Lopez has been a consultant to numerous agencies and organizations including the National Institutes of Health, the Department of Veterans Affairs, and the American Cancer Society. He was on faculty at the University of South Alabama College of Medicine in the Infectious Diseases department focusing on patient care, teaching, and research.

His academic research interest was on the molecular genetics of bacterial pathogenicity.

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He subsequently joined SmithKline Beecham's now GlaxoSmithKline anti-infectives clinical group and later progressed to global head of the Consumer Healthcare division Medical and Regulatory group. Morse received his Ph. Previously, Dr. He has published more than articles and abstracts on various emerging infectious disease problems and is the author of the best selling book, Living Terrors: What America Needs to Know to Survive the Coming Bioterrorist Catastrophe. He is past president of the Council of State and Territorial Epidemiologists. GARY A. Roselle serves on several national advisory committees.

He has been an invited speaker at several national and international meetings, and has published over 80 papers and several book chapters. Before joining Wyeth, Dr. His major research interest has been the mechanisms and epidemiology of antimicrobial resistance in bacteria, in which area he has published widely.

He has recently become more involved in the area of public policy as it relates to the discovery and development of antibiotics. She is responsible for managing the legislative and regulatory affairs of this 42,member organization, the largest single biological science society in the world.

Antibiotic resistance

Department of State, and as a freelance editor and writer. She received her baccalaureate, cum laude, from the University of Massachusetts, and is a graduate of the George Washington University programs in public policy and in editing and publications. She has co-authored published articles on research funding, biotechnology, biological weapons control, and public policy issues related to microbiology. He was president of the Infectious Disease Society of America in — Sparling's laboratory research is in the molecular biology of bacterial outer membrane proteins involved in pathogenesis, with a major emphasis on gonococci and meningococci.

His current studies focus on the biochemistry and genetics of iron-scavenging mechanisms used by gonococci and meningococci and the structure and function of the gonococcal porin proteins. He is pursuing the goal of a vaccine for gonorrhea. Agency for International Development. Zeilinger serves as the senior advisor and manager of the infectious disease strategic objective team which encompasses four sub-teams: malaria, tuberculosis, antimicrobial resistance, and surveillance.

His work in Central Asia also included humanitarian assistance and child survival programs. Zeilinger is a Doctor of Podiatric Medicine and managed several community health programs during his surgical residency. BELL, M. In this capacity, he coordinates CDC's efforts to address antimicrobial resistance. He is also co-chair of the U.

From to , Dr. Bell directed CDC's efforts to assess and reduce the risk of HIV transmission to workers and patients in healthcare settings. Previously, he was Director of the Diagnostic Virology Laboratory at the University of Tennessee, Memphis, and practiced general pediatrics. He is co-author of 90 scientific publications and book chapters dealing with the public health, clinical, and laboratory aspects of infectious diseases. Bell graduated from Princeton University A.

With over 24 years as a research entomologist with the CDC, Dr. Brogdon has developed an applied research program on insecticide resistance in arthropod vectors of disease. Studies have been conducted both in the United States and in 20 countries on insecticide resistance in Aedes, Culex, and Anopheles mosquito vectors. Brogdon has developed novel biological, biochemical, and molecular approaches to detecting insecticide resistance and its mechanisms in individual insects.

His work contributed to the recommended therapy for sepsis in victims of radiation accidents, development of combined therapy with non-specific biological response modifiers together with antimicrobial agents, and the discovery that pulmonary infections of Bacillus anthracis induce a unique polymicrobial sepsis following sub-lethal doses of gamma radiation.

Elliott was a clinical chemist, performed industrial microbiological studies, and taught microbiology and immunology at The George Washington University and the Foundation for Advancement of Education in the Sciences, National Institutes of Health. He is currently serving on two advisory committees, which are coordinated by the Office of Science and Technology Policy, Executive Office of the President, on inactivation of microorganisms and the Interagency Working Committee on Test Methods and Surrogates for Anthrax, Environmental Protection Agency.


  • Antibiotic resistance.
  • Project MUSE - Books Received.
  • Ching-Ching the Snoopy Schnauzer.

Army Specific Military Requirements, U. Army Nuclear and Chemical Agency. He has been editor-in-chief of the scientific journal Infection and Immunity for 10 years, and serves as advisory editor for the Journal of Experimental Medicine and Trends in Microbiology. Fischetti serves on the scientific advisory board and as trustee of the Trudeau Institute. He has published approximately primary research articles and 77 textbook chapters as well as being an inventor on over 37 issued patents.

Fischetti received a Ph. His research career has been directed toward the understanding of infection by gram-positive bacteria. He has focused his attention on group A streptococcus and has developed new strategies to control infection by these bacteria. He currently has a vaccine in clinical trial to control strep infections and a novel target for antibiotic development being tested by a major pharmaceutical company. In recent years he has directed his attention to the use of bacteriophage lytic enzymes to control colonizing pathogenic bacteria, particularly those that are resistant to current antibiotics.

She earned her B. She earned her M. She has served as chair and co-chair of the IDSA's Committee on Professional Development and Diversity and co-chair of the Annual Program Committee, and was elected to serve as a member of the nominations committee. Her editorial activities have included appointments to the Editorial Board, Annals of Internal Medicine ; Associate Editor, American Journal of Medicine , and service as a peer reviewer for numerous journals.

MARK J. He did his postgraduate training at the Presbyterian Hospital in New York City and with the Centers for Disease Control and Prevention and is board-certified in internal medicine and infectious diseases and a fellow of the Infectious Diseases Society of America. Goldberger was on the faculty of Columbia University for nine years and has been with the Food and Drug Administration since This office is responsible for the regulation of all anti-infective drugs as well as drugs for solid organ transplantation.

He also serves as the lead in coordinating drug shortage activities within the Center. He is responsible for the implementation of global and national antimicrobial resistance containment strategies, including infection control activities. This work also includes the development and implementation of training materials for international drug and therapeutics committee training courses. Green is a pharmacist with 22 years of experience with the U. Public Health Service and 4 years experience in international health. Experience includes serving on drug and therapeutics committees, development and implementation of pharmacy quality assurance programs, providing drug information services, and development of pharmacy-based primary care programs.

International experience prior to working with Management Sciences for Health includes pharmacy assessments in Montenegro, Nicaragua, Micronesia, the Virgin Islands, and three years of pharmacy development work in the Republic of Palau. She received her B.

Drug companies aren’t making new antibiotics. Is there an economic cure?

Her major research interests are the development and spread of insecticide resistance in insect vectors of disease. Hemingway currently has a research group of 33 scientists at post-doctoral and post-graduate levels looking at numerous aspects of resistance from the molecular biology of resistance gene amplification and control of resistance gene expression, through positional cloning for resistance gene identification, to field-based resistance management programs in Africa and Latin America.

The group is also looking at the interaction of insecticide resistance and vectorial capacity in filarial and malarial systems using genomic approaches. In addition to publications in academic journals on health care, health insurance, and public economics, he has written Principles of Health Economics for Developing Countries , a text published through the World Bank for health policy makers, students, and researchers.

KING, M. He received his B. His current research focuses on the modeling of transmission of infectious diseases and the prevention of disease due to helminthic infections. He is director of two NIH-funded research projects based in Coast Province, Kenya, which focus, respectively, on the ecology of Schistosoma haematobium transmission and on drug-based control of human urinary schistosomiasis.

An Economic Approach, 1st Edition

Laxminarayan received his undergraduate degree in engineering from the Birla Institute of Technology and Science in Pilani, India, and both his master's degree in public health and doctorate in economics from the University of Washington in Seattle. His research deals with the integration of epidemiological models of infectious disease transmission and acquisition of bacterial and parasite resistance into the economic analysis of public health problems. He has worked with WHO on evaluating malaria treatment policy in Africa, has organized two conferences on the Economics of Resistance, and is editor of a forthcoming book, Battling Resistance to Antibiotics and Pesticides: An Economic Approach.

LEVY, M. He also serves as President of the Alliance for the Prudent Use of Antibiotics, an international organization with members in over countries. He is a past president of the 42, member American Society for Microbiology. Levy has published over papers on antibiotic use and resistance, and has edited four books and two special journal editions devoted to the subject. He has organized and chaired four international meetings on drug resistance and was Chairperson of the NIH Fogarty Center three-year international study of antibiotic use and resistance worldwide.

He was awarded the Hoechst-Roussel Award for esteemed research in antimicrobial chemotherapy by the American Society for Microbiology. He was awarded an honorary degree in biology from Wesleyan University in and one from Des Moines University in Levy has been featured and quoted for his work on antibiotic use and resistance in major national and international newspapers and magazines including Time, Newsweek, U. In addition to overseeing all FDA international initiatives, he is responsible for leading the FDA response to several national public health issues that cut across several of the programmatic centers at FDA, including the agency's response to the threat of bovine spongiform encephalopathy BSE and antimicrobial resistance.

Lumpkin received his B. He completed a residency in pediatrics at the Mayo Clinic followed by a fellowship in pediatric infectious diseases. His professional certifications include pediatrics and tropical medicine. In he joined the FDA as Director of the Division of Anti-Infective Drug Products, Center for Drug Evaluation and Research CDER , which is charged with the primary oversight and approval responsibilities for drugs classified as antimicrobials as well as dermatological and ophthalmological drug products.

His prior professional experience includes working as a clinical worker in a refugee camp in Bangladesh; head of pediatric infectious diseases at East Tennessee Children's Hospital in Knoxville; and Medical Director at Abbott Laboratories where he was in a senior leadership position on the multidisciplinary, global team responsible for the worldwide development of a new antimicrobial clarithromycin.

He received his undergraduate and graduate degrees from the University of Southern California and the University of Chicago, respectively. After a two-year postdoctoral research program at the Rockefeller University, he joined the faculty at Wayne State University. He leads a multidisciplinary research group that integrates research in organic chemistry, biochemistry, molecular biology, structural biology, and computational sciences. The research interests of the group are diverse, spanning investigations of the mechanisms of drug resistance to antibiotics, development of novel classes of antibiotics, studies of the structural aspects of the bacterial envelope, and cancer metastasis.

He has served on numerous advisory committees for the government and the private sector. He is currently on the editorial boards of a number of scientific journals, serves on the Scientific Advisory Board of Newbiotics, Inc. Boniface Hospital in Winnipeg, Manitoba, Canada. Boniface Hospital. She has recently completed a sabbatical at WHO where she participated in development of the Global Strategy for Antimicrobial Resistance. Nicolle's research interests have been in hospital-acquired infections, infections in the elderly, and urinary tract infections.

She undertook undergraduate and graduate training in pharmacy and microbiology at Obafemi Awolowo University, Ile-Ife, Nigeria, where she studied the antibiotic resistance and virulence of fecal Escherichia coli. Since then, she has continued to research the antibiotic resistance and pathogenesis of E. Her current research focuses on the molecular epidemiology, pathogenesis, and antibiotic resistance of enterovirulent E. His research group engages in the study of rapid evolutionary change, including the genetics, evolution, conservation, population biology, and systematics of a diverse array of marine organisms.

Professor Palumbi has published on the genetics and evolution of a wide variety of organisms including sea urchins, whales, cone snails, corals, sharks, spiders, shrimps, bryozoans, and butterflyfishes. Norton , shows how rapid evolution is central to emerging problems in modern society, and has been cited for its easy readability by non-scientists. A primary research focus of his is the use of molecular genetic techniques in conservation, including for the identification of whale and dolphin products available in commercial markets. Current conservation work centers on the genetics of marine reserves designed for conservation and fisheries enhancement, with projects in The Philipppines, the Bahamas, and off the west coast of the United States.

In addition, basic work on the molecular evolution of reproductive isolation and its influence on patterns of speciation uses marine model systems such as sea urchins. This work is expanding our view of the evolution of gamete morphology and the genes involved. PECK, Ph. He completed his Ph. This work was used by the EPA to set refuge sizes for delaying resistance development in transgenic crops.

Currently he is assistant professor in the Zoology Department of Brigham Young University where he continues to work on modeling the spatial aspects in the spread of resistance and on rates of evolution in spatially subdivided populations. The center has a multi-disciplinary staff of researchers who are involved in field research in Peru, Belize, and Thailand.

Roberts has 94 peer-reviewed publications, with several others in press, under review, or in preparation. His special area of interest is malaria control, especially the control of malaria by spraying insecticide residues on house walls. Blake Scott. Carbondale: Southern Illinois University Press, Katie Hogan.

Ramanan Laxminarayan. Washington, DC: Resources for the Future, Fred E. Foldvary and Daniel B. Klein, eds. Jeffrey D. Geneva: World Health Organization, Joseph P. Cambridge: MIT Press, Ruth McDonald. David I. Levine, Frank W. Newhauser, Richard Reuben, Jeffrey S. Petersen, and Cristian Echeverria. Kalamazoo, MI: W. Upjohn Institute for Employment Research, Avedis Donabedian. Oxford: Oxford University Press, Tristram Engelhardt Jr. Rasmussen, eds. Boston: Kluwer, Robert A. Ethical Dimensions of Health Policy.

Marion Danis, Carolyn M. Clancy, and Larry R. William B. Bondeson and James W.


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